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An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer
Background: Metastatic breast cancer (MBC) is incurable, with a 5-year survival rate of 28%. In the USA, more than 42,000 patients die …
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An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer
Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC …
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Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4 + T Cells That Subvert Immunosuppression
Immunotherapy has potential to prevent and treat metastatic breast cancer, but strategies to enhance immune-mediated killing of …
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Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4 + T Cells That Subvert Immunosuppression
A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of …
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A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion
Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood …
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Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion
Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus
Intracranial (i.c.) infection of susceptible C57BL/6 mice with the neurotropic JHM strain of mouse hepatitis virus (JHMV) (a member of …
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Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system
The present study examines functional contributions of microglia in host defense, demyelination, and remyelination following infection …
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Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system
CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments
Background: Single cell RNA sequencing (scRNAseq) has provided invaluable insights into cellular heterogeneity and functional states in …
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CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments
T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation
Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice …
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T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation
Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade
The presence and activity of CD8+ T cells within the tumor microenvironment are essential for the control of tumor growth. Utilizing …
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