Dr. Atakan Ekiz
Dr. Atakan Ekiz
Lab
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Türkçe
English
2
An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer
Background:
Metastatic breast cancer (MBC) is incurable, with a 5-year survival rate of 28%. In the USA, more than 42,000 patients die …
Scherer SD
,
Riggio AI
,
Haroun F
,
Derose YS
,
Ekiz HA
,
Fujita M
,
Toner J
,
Zhao L
,
Li Z
,
Oesterreich S
,
Samatar AA
,
Welm AL
PDF
DOI
Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition
Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC …
Stephens WZ
,
Kubinak JL
,
Ghazaryan A
,
Bauer KM
,
Bell R
,
Buhrke K
,
Chiaro TR
,
Weis AM
,
Tang WW
,
Monts JK
,
Soto R
,
Ekiz HA
,
O'Connell RM
,
Round JL
PDF
DOI
Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4 + T Cells That Subvert Immunosuppression
Immunotherapy has potential to prevent and treat metastatic breast cancer, but strategies to enhance immune-mediated killing of …
Lai SA
,
Gundlapalli H
,
Ekiz HA
,
Jiang A
,
Fernandez E
,
Welm AL
PDF
DOI
A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of …
Huffaker TB
,
Ekiz HA
,
Barba C
,
Lee S
,
Runtsch MC
,
Nelson MC
,
Bauer KM
,
Tang WW
,
Mosbruger TL
,
Cox JE
,
Round JL
,
Voth WP
,
O'Connell RM
PDF
DOI
Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion
Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood …
Cortes-Selva D
,
Gibbs L
,
Ready A
,
Ekiz HA
,
O'Connell RM
,
Rajwa B
,
Fairfax CF
PDF
DOI
Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus
Intracranial (i.c.) infection of susceptible C57BL/6 mice with the neurotropic JHM strain of mouse hepatitis virus (JHMV) (a member of …
Syage AR
,
Ekiz HA
,
Skinner DD
,
Stone C
,
O'Connell RM
,
Lane TE
PDF
DOI
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system
The present study examines functional contributions of microglia in host defense, demyelination, and remyelination following infection …
Mangale V
,
Syage AR
,
Ekiz HA
,
Skinner DD
,
Cheng Y
,
Stone CL
,
Brown RM
,
O'Connell RM
,
Green KN
,
Lane TE
PDF
DOI
CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments
Background:
Single cell RNA sequencing (scRNAseq) has provided invaluable insights into cellular heterogeneity and functional states in …
Ekiz HA
,
Conley CJ
,
Stephens WZ
,
O'Connell RM
PDF
Kod
DOI
T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation
Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice …
Ekiz HA
,
Ramstead AG
,
Lee S
,
Nelson MC
,
Bauer KM
,
Wallace JA
,
Hu R
,
Round JL
,
Rutter J
,
Drummond MJ
,
Rao DS
,
O'Connell RM
PDF
DOI
Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade
The presence and activity of CD8+ T cells within the tumor microenvironment are essential for the control of tumor growth. Utilizing …
Snook JP
,
Soedel AJ
,
Ekiz HA
,
O'Connell RM
,
Williams MA
PDF
DOI
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