Welm AL

En güncel

• An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer
• Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4 + T Cells That Subvert Immunosuppression
• Inhibition of RON kinase potentiates anti-CTLA-4 immunotherapy to shrink breast tumors and prevent metastatic outgrowth
• RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
• Survivin promotion of melanoma metastasis requires upregulation of α5 integrin
• Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity